Corticosteroid Therapy in Patients with Autoimmune Diseases of the Central Nervous System Takuya Matsushita 1 1Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University Keyword: ステロイド , 自己免疫性疾患 , corticosteroid , autoimmune diseases pp.408-413
Published Date 2021/5/1
DOI https://doi.org/10.11477/mf.1416201779
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Corticosteroids play an important role in the treatment of inflammatory disorders including neuroinflammatory diseases. Corticosteroids with glucocorticoid receptors directly regulate transcription of many genes associated with inflammation and interfere with pro-inflammatory transcription factors. Glucocorticoids produce non-genomic effects by intercalation into the plasma membrane. These effects differ depending on the immunophenotype of immune cells. The corticosteroid dosage that is effective against inflammatory disorders depends on the pathological background of autoimmune diseases; however, owing to limited clinical evidence, the dosage has been empirically determined in routine medical practice. The corticosteroid dosage should be <7.5mg prednisolone equivalent/day to reduce the risk of adverse effects associated with these drugs.

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