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Pathology of Opportunistic Infection of the Central Nervous System Masayuki Shintaku 1 1Department of Pathology, National Hospital Organization Kyoto Medical Center Keyword: 日和見感染症 , 中枢神経系 , 病理組織像 , opportunistic infection , central nervous system , histopathology pp.903-917
Published Date 2015/7/1
DOI https://doi.org/10.11477/mf.1416200230
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Abstract

Opportunistic pathogens affecting the central nervous system include bacteria, fungi, protozoa, and viruses, and infection with these microorganisms exhibits varied histopathological findings. In opportunistic infections, the inflammatory and reparative mechanisms of the affected tissues are generally weak, reflecting a decrease of the protective immunological response of the host. In recent years, the so-called "immune reconstitution inflammatory syndrome," which is caused by abrupt restoration of the immunological activity due to therapy, has emerged as a new clinicopathological problem, especially in acquired immunodeficiency syndrome patients. In this comprehensive review, detailed classical histopathological descriptions on the various aspects of opportunistic infection affecting the central nervous system are provided, with the intention to provide a basis for further molecular pathological studies.


Copyright © 2015, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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