Dopamine and NMDA Receptors in Basal Ganglia Circuits and Their Roles regarding Motor Control and Learning Nae Saito 1,2 , Toshikuni Sasaoka 1 1Department of Comparative and Experimental Medicine, Brain Research Institute, Niigata University 2Department of Molecular and Cellular Medicine, Graduate School of Medical and Dental Sciences, Niigata University Keyword: 大脳基底核 , ドーパミン受容体 , NMDA受容体 , basal ganglia , dopamine receptor , NMDA receptor pp.1135-1142
Published Date 2020/11/1
DOI https://doi.org/10.11477/mf.1416201666
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Dopamine (DA) plays an important role in the basal ganglia (BG) for motor control, and DA deficiency as seen in Parkinson's disease, causes movement disorders. DA activates the direct pathway nerve via the D1 receptor (D1R) and inhibits the indirect pathway nerve via the D2 receptor (D2R). To understand the role of DA signaling, we review recent studies of the roles of D1R and D2R with respect to motor control, neural activity and memory learning using genetically engineered mice, and investigate their involvement in the BG oscillation phenomenon.

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