BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 71, Issue 9 (September 2019)

Drug Repositioning for Alzheimer's Disease Masafumi Ihara 1 , Satoshi Saito 1 1Department of Neurology, National Cerebral and Cardiovascular Center Keyword: リポジショニング , リパーパシング , リプロファイリング , 創薬 , 神経血管アプローチ , repositioning , repurposing , reprofiling , drug discovery , neurovascular approach pp.961-970
Published Date 2019/9/1
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To date, all clinical trials of disease-modifying drugs for Alzheimer's disease (AD) have been unsuccessful, making investments into AD drug development very risky despite the high unmet need. Drug repositioning or repurposing approaches are relatively less expensive and more promising compared to novel drug development in AD. About 40% of clinical trials for AD currently in progress across the world use the drug repositioning method. They are expected to be a trigger for AD drug discovery that breaks the current deadlock situation. By using drugs approved for other indications, these clinical trials target dysregulated pathways of AD with different or a combination of modes of action, including anti-amyloid, anti-tau, anti-inflammatory, metabolic, neuroprotective, and neurotransmission-based approaches. In these clinical trials, cardiovascular drugs such as insulin, cilostazol, probucol, telmisartan, and dabigatran are tested for their effect on different mechanisms of AD pathology. This is in line with the recent emphasis that AD should be studied as a complex multifactorial disorder, not dominated by one dominant biological factor such as beta-amyloid, and without disregarding any relevant pathologic factor, such as vascular dysregulation. It is strongly expected that drug repositioning approaches will create a paradigm shift in treatment approaches for AD patients.

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BRAIN and NERVE-神経研究の進歩
71巻9号 (2019年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院