BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 71, Issue 9 (September 2019)

Development of a Novel Treatment for Neurological Disorders by Drug Repositioning Satoshi Saito 1,2,3,4 , Masafumi Ihara 1 1Department of Neurology, National Cerebral and Cardiovascular Center 2Japan Society for the Promotion of Science 3Faculty of Medicine, University of Southampton 4Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University Keyword: ドラッグ・リポジショニング , ドラッグ・リプロファイリング , 脳神経内科 , アドレノメデュリン , シロスタゾール , drug repositioning , drug reprofiling , neurology , adrenomedullin , cilostazol pp.936-942
Published Date 2019/9/1
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The aim of drug repositioning is to identify and develop new uses for existing drugs. Many drugs for neurological disorders have been established by drug repositioning. Conventional drug repositioning approaches are based on chance findings or close clinical observations. Nowadays, computational drug repositioning can complement these approaches. Drug repositioning has many advantages. For example, unexpected adverse events occur less frequently in clinical trials using repositioned drugs than in trials with new drugs because safety information for repositioned drugs has often already accumulated before the start of a clinical trial. Another advantage is that drug repositioning can shorten the time needed for drug development and thereby reduce costs related to drug innovation. If results of pharmacological and toxic tests are available, pre-clinical studies may also be omitted. Drug repositioning is especially promising in the development of treatments for neurodegenerative disorders because the development of new drugs for chronic disorders often takes more than 20 years and has a high financial burden. Strategic patenting is important to cooperate with pharmaceutical companies and to accomplish drug repositioning.

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BRAIN and NERVE-神経研究の進歩
71巻9号 (2019年9月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院