BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 71, Issue 2 (February 2019)

Positron Emission Tomography Imaging for Oxidative Stress in Mitochondrial and Neurodegenerative Diseases Masamichi Ikawa 1,2,3 , Hidehiko Okazawa 3 , Makoto Yoneda 3,4 1Department of Advanced Medicine for Community Healthcare, Faculty of Medical Sciences, University of Fukui 2Department of Neurology, University of Fukui Hospital 3Biomedical Imaging Research Center, University of Fukui 4Faculty of Nursing and Social Welfare Science, Fukui Prefectural University Keyword: 酸化ストレス , ミトコンドリア病 , 神経変性疾患 , PETイメージング , 62Cu-ATSM , oxidative stress , mitochondrial diseases , neurodegenerative disorders , PET imaging pp.161-166
Published Date 2019/2/1
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Oxidative stress and mitochondrial dysfunction are assumed to be the pathogenic molecular mechanisms underlying various neurodegenerative diseases. We applied positron emission tomography (PET) with [62Cu] diacetyl-bis (N4-methylthiosemicarbazone) (62Cu-ATSM) to image cerebral oxidative stress based on mitochondrial dysfunction in living patients. In our previous study, we observed an increased retention of Cu-ATSM in in vitro cell lines with mitochondrial respiratory failure, suggesting that 62Cu-ATSM uptake can be a promising biomarker for evaluating oxidative stress in patients with mitochondrial or neurodegenerative diseases. PET imaging with 62Cu-ATSM successfully demonstrated the increased uptake in brain lesions of a patient with mitochondrial disease (MELAS), in the striatum of patients with Parkinson's disease, and in the motor cortex and motor-related cortices of patients with amyotrophic lateral sclerosis. The uptake for these disease-related brain regions strongly correlated with disease severity, indicating that oxidative stress based on mitochondrial dysfunction is associated with the neurodegenerative process in these diseases. 62Cu-ATSM PET imaging for oxidative stress has improved our insights into the pathological mechanisms of neurodegenerative diseases and may be a promising tool for monitoring further antioxidant and mitochondrial therapies.

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BRAIN and NERVE-神経研究の進歩
71巻2号 (2019年2月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院