Association between the Thalamus and Social Function in Schizophrenia Daisuke Koshiyama 1 , Kiyoto Kasai 1,2 1Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo 2The International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS) Keyword: 統合失調症 , 視床 , 社会機能 , MRI , DTI , schizophrenia , thalamus , social function , magnetic resonance imaging , diffusion tensor imaging pp.155-160
Published Date 2019/2/1
DOI https://doi.org/10.11477/mf.1416201235
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Patients with schizophrenia face several difficulties in their daily social life owing to the impairment of social cognitive ability. However, the neural basis of this impairment has not been fully clarified. We attempted to identify the neuronal basis of social dysfunction of schizophrenia by focusing on the thalamus, which is a subcortical structure. We have shown that right thalamic volume, as well as white matter integrity between the right thalamus and right frontal lobe, is associated with the social function of patients with schizophrenia, by using T1-weighted magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) data. These findings suggested that neural network abnormalities between the thalamus and the frontal lobe can be related to social dysfunction in patients with schizophrenia. Thus, these findings may contribute to the development of new treatments for schizophrenia.

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