BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 11 (November 2018)
Japanese

Time and Self in Episodic Memory and Confabulation Saeko Iwata 1,2 , Takashi Tsukiura 1 1Department of Cognitive and Behavioral Science, Graduate School of Human and Environmental Studies, Kyoto University 2Japan Society for the Promotion of Science Keyword: 作話 , 前脳基底部 , エピソード記憶 , 時間 , 自己 , confabulation , basal forebrain , episodic memory , time , self pp.1203-1208
Published Date 2018/11/1
DOI https://doi.org/10.11477/mf.1416201165
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Abstract

Confabulation is defined as the production of narrative descriptions of events that never happened, and is often observed in amnesia with basal forebrain lesions. However, little is known about the possible mechanisms related to confabulation. In this review article, we summarized previous neuropsychological and neuroimaging studies associated with confabulation, and proposed a hypothetical mechanism of confabulation. Previous studies have demonstrated that amnesic patients with confabulation after basal forebrain damage are impaired in the processing of time-related information in episodic memory and that activation of this region is significant during the processing of time-related information in episodic memory. In addition, confabulating patients with basal forebrain lesions extending to the medial prefrontal cortex (mPFC), medial temporal, and thalamic regions are likely to show significant disturbances in age-awareness and significant false memories in personally experienced events. Given the importance of the mPFC in the self-referential process and of the hippocampus in the integration of episodic components, the basal forebrain region could play an important role in orienting the self in time by acting as an interface between the mPFC and the hippocampus. Confabulation in basal forebrain amnesia could be caused by a decline of the time-self interaction.


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基本情報

18816096.70.11.jpg
BRAIN and NERVE-神経研究の進歩
70巻11号 (2018年11月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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