BRAIN and NERVE Shinkei Kenkyu no Shinpo Volume 70, Issue 8 (August 2018)

Autonomic Dysfunction and Skin Biopsy in Dementia with Lewy Bodies Satoshi Orimo 1 1Department of Neurology, Kanto Central Hospital Keyword: レヴィ小体病 , 起立性低血圧 , MIBG心筋シンチグラフィ , 皮膚生検 , αシヌクレイン , Lewy body disease , orthostatic hypotension , MIBG cardiac scintigraphy , skin biopsy , α-synuclein pp.915-927
Published Date 2018/8/1
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Neuropathological hallmarks of Lewy body disease including Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are Lewy bodies in not only the central nervous system but also the peripheral autonomic nervous system. α-synuclein is a presynaptic protein, and is a major constituent of Lewy bodies. The peripheral autonomic nervous system innervates various organs such as the gastrointestinal tract, the heart, the bladder, and the skin. Severe autonomic dysfunction is one of the supportive clinical features of DLB, and reduced cardiac MIBG uptake is an indicative biomarkers of DLB according to the revised criteria for the clinical diagnosis of DLB in 2017. Recently, it was reported that α-synuclein deposits in various biopsied tissue samples, particularly in the skin, can act as a possible biomarker to diagnose PD. Above approach was conducted by using skin biopsies from patients with DLB. Phosphorylated α-synuclein deposits in the skin were found in all patients with DLB, but not in patients with non-synucleinopathy dementia or controls, suggesting that phosphorylated α-synuclein can potentially act as a diagnostic biomarker in DLB.

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BRAIN and NERVE-神経研究の進歩
70巻8号 (2018年8月)
電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院