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Autonomic Dysfunction in Tauopathies Shunsuke Koga 1 , Ikuko Aiba 2 1Department of Neuroscience, Mayo Clinic 2Department of Neurology, National Hospital Organization Higashinagoya National Hospital Keyword: 自律神経障害 , 排尿障害 , 起立性低血圧 , 進行性核上性麻痺 , 大脳皮質基底核変性症 , autonomic failure , urinary dysfunction , orthostatic hypotension , progressive supranuclear palsy , corticobasal degeneration pp.257-262
Published Date 2022/3/1
DOI https://doi.org/10.11477/mf.1416202021
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Abstract

Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) are tauopathies that clinically present with atypical parkinsonism. Autonomic dysfunction is known to occur in synucleinopathies, particularly in cases of multiple system atrophy; however, the frequency and features of autonomic dysfunction in patients with tauopathies remain unclear. Recent studies have reported that urinary dysfunction and constipation are common and affect the prognosis of patients with PSP. In contrast, neurogenic orthostatic hypotension is rare in PSP, which is useful to distinguish PSP from multiple system atrophy and Lewy body disease. Urinary dysfunction is also commonly observed in patients with CBD and serves as an inclusion criterion for PSP syndrome in patients with CBD. However, this finding is not validated in other cohorts; therefore, further studies are warranted to confirm the usefulness of this criterion.


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電子版ISSN 1344-8129 印刷版ISSN 1881-6096 医学書院

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