健康長寿社会の実現を目指した大規模認知症コホート研究（JPSC-AD）

Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD)

わが国は超高齢社会を迎えて認知症の急増が医療・社会問題となっている。そのため，生命科学の研究手法を融合させたコホート研究によって，認知症の危険因子を同定し，その病態を解明する必要がある。本研究では，全国8地域において地域高齢者1万人から成る認知症コホート研究を設立する。各地域で標準化された調査項目や診断基準などのデータを収集する。さらに，基礎研究の知見を積極的に活用し，認知症の病態解明と予防法の確立を目指す。

Abstract

Dementia has become a priority worldwide in terms of both public health and social care due to its rapidly increasing burden in communities. Therefore, the early identification of possible risk factors and the establishment of preventive and treatment strategies for dementia have become increasingly important. The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a collaborative prospective cohort study of approximately 10,000 elderly people from 8 newly established community-based dementia cohort studies in Japan. In this study, the data are prospectively collected using a pre-specified standardized protocol. The purpose of this study is to quantitatively evaluate the environmental and genomic risk factors for dementia in Japan and to establish effective preventive strategies to promote a healthy aging society.