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52歳,男性。1997年1月,他院で左腎腫瘍を指摘され当科を受診した。多血症と血中エリスロポイエチン(以下EPO)濃度の上昇を認め,胸腹部CTで左腎腫瘍および多発性肺転移と診断した。左根治的腎摘除術を施行,病理組織学的診断は腎細胞癌pT3a,pNO,G2であった。術後,血中EPO濃度は正常化し,腫瘍組織中EPO濃度の増加と.抗EPO抗体を用いた免疫組織化学染色で腫瘍細胞に染色性を認め,EPO産生腎癌と診断した。血中,腫瘍組織中EPO濃度上昇と,抗EPO抗体使用による免疫組織染色で癌組織中のEPO局在を同時に示し得た症例は自験例が最初と考えられた。
A 52-year-old male. The patient visited our department on January 1997 after he was pointed out of left renal tumor at other hospital. He had polycythemia and showed in-creased serum erythropoietin ("EPO" hereinafter) con-centration. Based on the CT scan findings, he was diagnosed the left renal tumor and multiple lung metastasis. Accord-ingly, left radical nephrectomy was performed. The histo-pathological diagnosis was renal cell carcinoma in pT3a, pNO, G2. After the radical nephrectomy, the serum EPO concentration became normal level.
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