尿失禁を有する女性過活動膀胱患者に対するイミダフェナシンの効果

Effectiveness of imidafenacin on urinary incontinence, quality of life, and urodynamics in women with overactive bladder

　過活動膀胱（OAB）患者に対するイミダフェナシンの効果を尿流動態検査，症状ならびにQOLの面から検討した．当院に通院中の20歳以上の尿失禁を有する女性OAB患者41例を対象とした．イミダフェナシン0.2mg/日を8〜10週間投与し，投与前後で過活動膀胱の問診チェックシート（OABSS），尿失禁症状・QOL評価質問票（ICIQ-SF），キング健康調査票（KHQ），尿失禁日誌，尿流動態検査を実施した．有効性評価対象は33例だった．OABSS，ICIQ-SF，昼間尿失禁回数，尿パッド使用枚数はいずれも投与後に有意に改善した．尿流動態検査では膀胱容量が増加し，13例中7例で排尿筋過活動の消失を認めた．イミダフェナシンは尿失禁を有する女性OAB患者に対し，有用であると考えられた．

Abstract

The purpose of this study was to prospectively evaluate the effectiveness of imidafenacin on symptoms, QOL and urodynamics in women with urinary incontinence associated with overactive bladder. Female patients aged 20 years or older with OAB accompanied by urinary incontinence were enrolled at Kameda Medical Center and assigned to receive oral imidafenacin 0.1mg twice daily for 8-10 weeks. The endpoints of this study were the number of urinary incontinence episodes and urine pad exchanges, OABSS, ICIQ-SF, KHQ and urodynamics before and after the treatment. A total of 33 patients were included in the efficacy analysis. In urodynamic testing, bladder volume at strong desire to void increased significantly. Detrusor overactivity (DO) resolved in 7 of 13 patients. The number of urinary incontinence episodes in daytime and urine pad exchanges, OABSS and ICIQ-SF were significantly improved. Efficacy of imidafenacin on symptoms and QOL may be explained by its ability to increase the bladder volume at greater sensation of urgency and improved DO. Imidafenacin is suggested to be effective in treating female OAB patients with urinary incontinence (Rinsho Hinyokika 72 : 847-851, 2018).