閉塞性水腎症に伴つたバゾプレッシン抵抗性尿崩症の1例

VASOPRESSIN-RESISTANT DIABETES INSIPIDUS ASSOCIATED WITH OBSTRUCTIVE UROPATHY: REPORT OF A CASE

緒言

　水腎症にバゾプレッシン抵抗性の尿崩症を併発することは知られているが，実際には臨床上で経験するのは稀である。今回，われわれは結腸癌の尿路系への浸潤により両側性の閉塞性水腎症の状態となり，それに続発したと思われるバゾプレッシン抵抗性尿崩症の1例を経験したので報告する。

A 38-year-old male was admitted to our hospital because of obstructive uropathy due to sigmoid colon cancer invasion to the urinary tract on February 20, 1984. The urine volume ranged from 3,000 ml to 13,000ml per day, and serum electrolytes values were as follows: sodium 179mEq/L, potassium 3.8mEq/L and chloride 142mEq/L. Injection of vasopressin was not effective, therefore diagnosis of vasopressin-resistant diabetes insipidus was made. Hydrochlorothiazide was not effective. He died of renal failure on April 4, 1984. Bilateral renal needle biopsy revealed atrophic tubulus throughout with almost intact glomerulus.