Cyclophosphamide投与中に膀胱腫瘍と悪性リンパ腫を併発した1例

OCCURRENCE OF BLADDER CANCER AND MALIGNANT LYMPHOMA DURING CYCLOPHOSPHAMIDE THERAPY FOR BREAST CANCER

緒言

　cyclophosphamideは現在広く使用されている制癌剤である。近年cyclophosphamideと膀胱腫瘍発生との関連性を示唆する報告が散見される。われわれも乳癌の転移巣へのcyclophosphamide長期投与中に膀胱腫瘍および悪性リンパ腫を併発した症例を経験したので，若干の文献的考察を加えて報告する。

A 68-year-old female received a total of 169g of cyclophosphamide for 5 years for pulmonary and vertebral metastasis from breast cancer. She visited us because of asymptomatic hematuria. Cystoscopy revealed a round and non-papillary bladder tumor with stalk. Total cystectomy was performed in April, 1981. As a tumor of the ileo-cecum junction was found incidentally, resection of the terminal ileum was also performed. Histological examination revealed a transitional cell carcinoma, grade III/IV of the urinary bladder which invaded the muscle layer and a malignant lymphoma, small cell type of the terminal ileum.