尿管結石症に対するDilospanの治験

CLINICAL APPLICATIONS OF "PHLORO-GLUCINOL" TO URETERAL CALCULI WITH PAIN

Ⅰ．緒言

　従来，泌尿器科領域における尿路結石症（とくに尿管結石症）の疝痛発作ひいては結石排出促進剤としてHyostin-N-buthylbromidとsulpyrinのcomplexがanti-parasympathomimetic drugとして主に用いられてきた。これに対し日本ルセル株式会社から提供を受けたDilospanはparasympaticsを介さず選択的に直接，尿管や胆管の平滑筋に働き，特に攣縮せる平滑筋の弛緩作用が強いといわれている。

　今回，われわれは薬理学的に興味ある本剤を，とくに疝痛発作や疼痛を有する尿管結石症に使用し，若干の治験をおさめたのでここに報告する。

Investigations were carried out to see the ana-lgestic and antispasmodic effects of Phloroglucinol on twenty one cases with ureteral calculi.

The results obtained are as follows;

1. In fifteen (71.4%) of twenty on with urete-ral calculi, analgestic effects were noticed.

2. An increase of colicy pain was seen in three cases (14.3%)

3. Side effects were not noticed except for two cases (9.9%)--thirst.

4. Phloroglucinol proved to be helpful in the treatment of cases of ureteral calculi with pain.