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Clinical outcomes of patients underwent radical prostatectomy in Tane general hospital:Interim-term results Hiromi Kumamoto 1 , Masaomi Kuwada 1 , Motokiyo Yoshikawa 1 , Satoshi Takada 1 , Yukinari Hosokawa 1 , Yoshiki Hayashi 1 , Nobumichi Tanaka 2 , Kiyohide Fujimoto 2 , Yoshihiko Hirao 2 1Department of Urology,Tane General Hospital 2Department of Urology,Nara Medical University Keyword: 前立腺全摘除術 , 前立腺腫瘍 pp.239-245
Published Date 2010/3/20
DOI https://doi.org/10.11477/mf.1413101918
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 Between January 1995 and December 2008,133 patients who underwent radical prostatectomy(RP) in Tane general hospital were enrolled to assess the interim-term clinical outcomes. We evaluated both estimated overall survival rate and biochemical recurrence free rate by using a Kaplan-Meier method. Furthermore predictors of biochemical recurrence in 95 patients without neoadjuvant and adjuvant therapy were assessed in univariate and multivariate analyses by Cox proportional hazards regression model. The 5-year overall survival rate and biochemical recurrence free rate were 95.4% and 67.9%,respectively. The 5-year biochemical recurrence free rate in patients(n=95)who underwent RP without neoadjuvant and adjuvant therapy was 60.4%. On multivariate analysis,preoperative serum prostate specific antigen(PSA),Gleason score at biopsy,seminal vesicle invasion and positive surgical margin were independent risk factors of biochemical recurrence in patients without neoadjuvant and adjuvant therapy. Overall survival rate in patients who underwent RP showed excellent results. Positive surgical margin was an independent predictor of biochemical recurrence. The development of surgical technique to avoid positive surgical margin would be expected to achieve a higher recurrence free rate.


Copyright © 2010, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1332 印刷版ISSN 0385-2393 医学書院

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