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FAMILIAR OCCURRENCE OF A DISCOID LUPUS ERYTHEMATOSUS-LIKE ERUPTION IN FOUR GENERATIONS Yoshihisa ISHIKAWA 1 , Teruo AZUMI 1 , Toshio KOBAYASHI 1 1Department of Dermatology, Nagoya University School of Medicine pp.829,861-868
Published Date 1970/9/1
DOI https://doi.org/10.11477/mf.1412200703
  • Abstract
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A family with a discoid l.e.-like eruption in 4 generations, which had 6 patients of 15 members, was reported. All cases showed a discoid l.e.-like eruption over the exposed areas, that is the faces, hands, feet, knees, and ear-lobes, which became worse in winter and better in summer. Some of the nails were deformed or fell off. While disturbance of movement of fingers and toes was noted, the roentgenograms failed to prove defects of their bones.

Onsets of the disease were within one year of age, and the paients were rather short of sta-Laboratory tests showed negative in tuberculin test, LE phenomenon and chromosome abnorma-lity, but positive in RA reaction, hypergammaglobulinemia and increased e.s.r..

Histologic specimens proved marked hyperkeratosis with parakeratosis but no liquefaction degeneration of the basal cell layer. Characteristic band-like lymphocytic infiltration and dilatation of the blood vessels were noted. The hyaline degeneration in some parts of the epidermis and hyaline droplets depositions in the upper parts of the dermis were proved.

They were diagnosed as a type of chilblain lupus.


Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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