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PURPURA HYPERGLOBULINEMICA Kozo SHIMANO 1 1Department of Dermatology, Kanazawa University, School of Medicine pp.361-367
Published Date 1970/4/1
DOI https://doi.org/10.11477/mf.1412200645
  • Abstract
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 A 32-year-old housewife had been suffering from attacks of purpura since 20 years of age, which appeared especially after long walks. In 1962 the purpura was accompanied with arthralgia, epistaxis and gingival bleeding. She had been pointed the disturbance of the heart by a doctor since her childhood.

 On February 7, 1963, she visited at first the dermatologic clinic of the University Hospital. She had small petechiae and livedo reticularis on the lower legs.

 Histologic specimen from the purpura on the lower leg showed slight perivascular infiltration in the upper and middle dermis composed of neutrophils, lymphocytes and nuclear fragments. The vascular wall showed edematous swelling, degeneration and bleeding.

 Histologic specimen from the inguinal lymph node showed proliferation of reticulum cells, accompanied with many plasma cells in some parts and some melanophores.

 Laboratory tests revealed normal bleeding and coagulation time and normal number of platelets, while anemia and strongly positive Rumpel-Leede's test were proved. The results of liver function tests, E. S. R., and serum protein showed extreme abnormalities. No Bence-Jones' protein was proved in the urine. Immunological and chemical analysis of the serum showed total protein 9.4-10.3 g/dl, γ-globulin 43.6-50.0% (Tiselius) , increased 7S globulin with normal amount of 19S (ultracentrifugation), and increased amount of IgG (immunoelectrophoresis), increased serum viscosity, slightly increased amount of fibrinogen and antitripsin ; cryoglobulin (-) , cryofibrinogen (-), LE test (-) , CRP (-) and RA (⧺).


Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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