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GENERALIZED GRANULOMA ANNULARE Yoshiaki SATOH 1 1Department of Dermatology, Tokyo Medical and Dental University pp.325,353-359
Published Date 1970/4/1
DOI https://doi.org/10.11477/mf.1412200644
  • Abstract
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A 56-year-old man found a pea-sized, annular lesion on the flexor aspect of the left forearm about 7 years ago, which enlarged gradually in spite of the topical application of various oint-ments. His familiar history had nothing contributive. He had chronic hepatitis which was under the medical care.

In November 1967, the similar lesions disseminated symmetrically almost over the entire body surface except the face, neck, scalp, and thigh. They were itchy temporalily.

The lesions consisted of red papules, 3 mm in diameter, or annular plaques with elevated borders, about 20 cm in diameter. The papules were infiltrated, and had a tendency to arrange annularly. On the hypogastrium there was a slightly depressed erythema. On the extensor surface of the fingers there were dome-shaped, up to 5 mm in diameter, cartilage-hard nodules.

Laboratory examination revealed a mildly positive tuberculin reaction, slight increase in β-, and γ globulin, disturbance of liver function, and positive STS, while there were no abnormality in the blood sugar level, urine, nor faeces.

Histologic specimen showed localized degeneration of collagenous fibers surrounded by lympho-histiocytic granulomatous infiltration.

The former contained the substance stained positive by the alcian blue and mucicarmin.

Treatment with local injection of glycocorticoid and application of ointment containing high dosis of glycocorticoid were successful.

The lesions became worse by Bicillin-V2 for the treatment of syphilis, Kowever they were improved. by a high fever due to an infection The mechanisms of these phenomena could not he clarified.


Copyright © 1970, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1324 印刷版ISSN 0021-4973 医学書院

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