各種皮膚疾患における免疫電気泳動法による血清蛋白の分析

ANALYSIS OF THE SERUM PROTEIN WITH IMMUNOELECTROPHORESIS IN VARIOUS SKIN DISEASES

はじめに

　1953年Grabar　＆　Williamsが免疫電気泳動法を創始して以来，皮膚科領域でも広く応用され，数種の皮膚疾患で特有の変化が認められている。今回著者らも各種皮膚疾患に対して本法を実施し，疾患特有の変化がみられるか否かを検討したのでその結果を報告する。

1) The serum protein was analysed with the cellulose acetate membrane immunoelectrophoresis in 25 healthy subjects. In our experiment 16 precipitation lines were almost constantly detected. The variations of the behavior of each precipitation band were observed and they were regarded as physiological. 2) In 163 patients with various skin diseases the serum was analysed with the same method. The statistically significant finding was an increase of intensity of α₂-macro-globulin in syphilis, especially tertiary one, and viral dermatoses. Compared with the allergic dermatoses, the nonallergic ones showed a significantly higher increase of α₂-macroglobulin. Although a statistical test was not performed because of a small number of cases, increases of α₂-lipoprotein and IgM in xanthoma, marked decreases of IgG, IgA and IgM in progressive vaccinia and an increase of α₂-macroglobulin in ichthyosis were thought to be the characteristic findings of respective dermatoses.