弾力線維性仮性黄色腫に続発したElastosis perforansの1例

ELASTOSIS PERFORANS SERPIGINOSA IN ASSOCIATION WITH PSEUDOXANTHOMA ELASTICUM

I．緒言

　1952年にLutz^1）が21歳男子に見られた頸項部の角化性蛇行性皮疹をKeratosis follicularisserpiginosaとして報告し，更にMiescher^2）が1955年に同様症例に詳細な組織学的検討を加え，Elastoma intrapapillare perstans verrucifor-meとして報告して以来，本症は欧米においては数十例の報告例が知られている。本邦においては，1961年に大森，肥田野により第1例が報告されて以来，長島，中村（2例），皆見，一原（1例）船橋，露木（1例），神畠（1例），の諸家により，6例の報告例がみられる^＊＊）。

　我々も最近典型的な弾力線維性仮性黄色腫に併発したElastosis．　Perforansの1例を経験したので，之について報告し，主に弾力線維性仮性黄色腫（以下PXEと約す）との関係について，文献学的考案を加えた。

A case of elastosis perforans serpiginosa on the upper arm and nape in a 28-year-old woman, who had been suffering from pseudoxanthoma elasticum for more than ten years, was reported.

Histologic specimen showed a giant epidermal cyst in the dermis, the bottom of which was perforated. There was a foreign body granuloma with giant cells and epithelioid cells in the dermis with typical change of pseudoxanthoma elasticum accompanied by calcium imbibition.

Only 3 cases of this disease accompanied by pseudoxanthoma elasticum have been reported in Europe and America, while all reported cases in Japan of this disease have been associated with pseudoxanthoma elasticum. A review of the literature especially on relationships between this disease and pseudoxanthoma elasticum was performed.