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I.はじめに
上顎癌患者に慢性副鼻腔炎の既往歴の多いことが報告1)されている。Burnet2)は発癌における免疫監視機構(immunological survcillance)の仮説を提唱したが,著者らは慢性副鼻腔炎患者の免疫監視機構に興味をもち,慢性副鼻腔炎ならびに上顎癌患者血清中,鼻汁中免疫抑制酸性蛋白(im—munosupprcssive acidic protein,以下IAPと略称)値が高値を示すことを報告3)した。今回はtwo-colorフローサイトメトリー分析4,5)を用いて慢性副鼻腔炎,上顎洞癌およびその他の鼻副鼻腔悪性腫瘍患者末稍血中のnatural killer (NK)活性細胞を測定し検討した。
Natural killer (NK) activity cells of patients with chronic sinusitis and maxillary cancer were observed by means of two-color flow cytometry.
Fluorescein isothiocyanate (FITC) and phyco-erythrin (PE) labelled monoclonal antibodies were used in these studies.
High score of Leu 7-11+ suggesting of high NK activity cells was observed in 6 of 8 patients with chronic sinusitis and 3 of 6 patients with maxillary cancer.
Low score of Leu 7-11+was observed in one patient with maxillary cancer.
These results might be helpful to investigate chronic sinusitis and maxillary cancer patients from a view point of immunological surveillance.
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