サルコイドーシスの臨床統計

Review of clinical features of sarcoidosis

　1991年から1997年に横浜市立大学医学部附属病院眼科を受診したサルコイドーシス患者91例について，診断方法，眼科的所見ならびに全身病変の合併についてretrospectiveに検討した。組織診断群は75例（82％）であり，経気管支肺生検および皮膚生検で診断された割合が高かった。また，眼症状を有する症例は68例（75％）であり，組織診断群と臨床診断群では後者に続発緑内障の頻度が有意に高かった以外，眼科的所見に差はみられなかった。一方，眼症状を有する群では顔面神経麻痺をはじめとする神経病変の合併頻度が高い反面，皮膚病変の合併頻度が有意に低く，眼症状の有無で全身病変の合併頻度に相違がみられた。

We reviewed a series of 91 patients of sarcoidosis seen by us during 7 years through 1997. We paid particular attention to the method of diagnosis, ocular involvement and systemic lesions. The diagnosis was confirmed histologically in 75 cases (82%), mainly by transbronchial lung or dermal biopsy. Ocular involvement was present in 68 cases (75%). There was no difference in ocular findings between cases diagnosed histologically and clinically, except a higher frequency of secondary glaucoma in clinically diagnosed cases. Cases of sarcoidosis with ocular involvement showed higher frequency of associated neurological lesions including facial nerve palsy and a lower frequency of skin lesions. The findings show that the presence of ocular lesions is related to the frequency of systemic manifestations.