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Elevated aqueous flare in patients with extraocular malignancy Ritsuko Yamada 1 , Tatsuma Watanabe 1 , Shigeru Kuriyama 1 , Yukiko Matsuo 1 , Masayuki Degawa 1 , Satoki Ueno 1 1Dept of Ophthalmol, St. Marianna Univ Sch of Med pp.335-338
Published Date 1999/3/15
DOI https://doi.org/10.11477/mf.1410906232
  • Abstract
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We quantitated the aqueous flare in 21 patients on repeated occasions using a laser flare cell meter. Malignancy had been present in 17 cases. In the other 4 cases, abnormal aqueous flare intensity led to the detection of systemic malignancy. The values were compared with those in 21 cases of sarcoidosis and 79 healthy persons. The malignancy patients showed sustained and slightly elevated flare intensitys, which were similar to those in sarcoidosis patients. The flare intensitys significantly decreased after initiation of treatment for malignancy. The decrease paralleled that in erythrocyte sedimentation rate and serum uric acid. The observed elevation in aqueous flare appeared to be due to breakdown of blood-aqueous barrier induced by tumor-related substances or inflammatory factors. The present findings show that elevated aqueous flare belongs to the paraneoplastic syndrome and may serve as a marker of remission or exacerbation of the tumor.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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