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Mikulicz syndrome in a case of mantle zone lymphoma Keiko Ushiyama 1 , Yoichi Minami 1 , Yoshie Matsui 1 , Shinji Oono 1 , Osamu Ushiyama 2 1Dept of Ophthalmol, Saga Med Sch 2Dept of Internal Med, Saga Med Sch pp.1571-1574
Published Date 1996/9/15
DOI https://doi.org/10.11477/mf.1410905038
  • Abstract
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A 57-year-old male presented with bilateral blepharoptosis of 6 months' duration. Fever and dyspnea had been present since 8 months before. He had noted swelling of parotid and submandibular glands for 8 years. He manifested, bilaterally, swollen lacrimal and salivary glands. Small papillary vesicules were present in the upper conjunctival fornices. Biopsy of the conjunctiva and the lung showed intermediate lymphocytic lymphoma (diffuse medium-sized cell type). The surface marker of tumor cells showed CD5 (+) CD10 (-). Chromosomal analysis of lymphoma cells showed t (11;14) (q13;q32). These findings led to the diagnosis of mantle zone lymphoma. Systemic treatments with corticosteroids and cytostatic agents led to improvement in ocular and systemic findings.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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