Immunohistological features of Mooren's corneal ulcer Jun Shoji 1 , Noriko Inada 1 , Keiko Saito 1 , Noriko Takaura 1 , Mitsuru Sawa 1 1Dept of Ophthalmol, Sch of Med Nihon Univ pp.599-602
Published Date 1995/4/15
DOI https://doi.org/10.11477/mf.1410904246
  • Abstract
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A 49-year-old male developed corneal perforation as complication of Mooren's ulcer. The conjunctival tissue obtained through lamellar keratoplasty was subjected to immunohistochemical studies. There were increases of neutrophils, plasma cells and lymphocytes which were positive for lymphocyte surface antigens CD4, CD8 and CD19. The subconjunctival tissue showed positive findings for IgG and IgA. Subconjunctival vessels were positive for adhesion molecule ICAM-1 and for HLA-DR. It appeared that presence of ICAM-1 was causatively related to the inflammatory reactions in Mooren's ulcer.

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