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Two cases of metastatic neuroblastoma to the orbit Shoko Yasuda 1 , Motohiro Kiyosawa 1 , Mitsuru Noro 1 , Mitsuko Tamaki 1 , Kazuhiro Haginoye 2 , Makoto Tamai 1 1Dept of Ophthalmol 2Dept of Pediat, Tohoku Univ Sch of Med pp.1537-1540
Published Date 1993/8/15
DOI https://doi.org/10.11477/mf.1410901813
  • Abstract
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We report metastatic neuroblastoma to the orbit in 2 boys aged 3 years and 7 months respectively. The initial manifestation was rapidly developing exophthalmos with ecchymosis in both cases. The original lesion was stage IV-A neuroblastoma in the adrenal gland. In the first case, routine screen-ing for urine vanillylmandelic acid (VMA) and homovanillic acid (HVA) was negative at the ageof 6 months. Chemotherapy was effective and the exophthalmos regressed after surgical resection of the adrenal tumor. In the second case, exophthal-mos further progressed in spite of chemotherapy. He died 3 months later. The findings illustrate that metastatic orbital neuroblastoma may induce retrobulbar hemorrhage and progressive exophthal-mos. Neuroblastoma has to be ruled out first by urine VMA-HVA test in children with rapidly developing orbital tumor.


Copyright © 1993, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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