遷延性原田病における前眼部炎症の定量的分析

Quantitation of aqueous flare and cells in protracted cases of Vogt-Koyanagi-Harada disease

　遷延性原田病7例13眼の前眼部炎症をレーザーフレアー・セルメーターにより定量的に解析した。レーザーフレアー・セルメーターによって得られた前房フレアー強度は，対象とした全例で細隙灯顕微鏡による前房フレアー所見とよく一致した。観察期間中のフレアー値の最低値は正常者に比較して有意に高い値を示し，長期間の前眼部炎症の継続と血液—房水柵破壊の存在が示唆された。細隙灯顕微鏡による前眼部炎症の評価とともにレーザーフレアー・セルメーターによる前房フレアーの定量的測定の導入によって，原田病などの内因性ぶどう膜炎の病勢分析がより詳細に行える可能性が考えられた。

We measured the intensity of aqueous flare and number of cells in 13 eyes of 7 protracted cases of Vogt-Koyanagi-Harada disease. The duration of the disease ranged from 30 months to 28 years, average 10.4 years. We quantitated the aqueous flare and cells over an average period of 13.3 months, using a laser flare-cell meter. The values for aqueous flare were expressed as equivalents of bovine serum albumin concentration. The maxi-mum flare intensity for each case ranged from 92 to 4678 mg/dl, the median from 46 to 982 mg/dl and the minimum from 38 to 437 mg/dl. The flare inten-sity in 24 eyes of 12 age-matched normal controls ranged from 19 to 39 mg/dl. The minimum values for flare intensity in the patients were significantly higher than those of controls. The findings indicat-ed that the blood-aqueous barrier was in disrupted state in protracted cases of Vogt-Koyanagi-Har-ada disease.