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Changes in optic disc structure and blood flow waveform following trabeculectomy Yui Takahashi 1 , Nobuko Enomoto 1 , Kyoko Ishida 1 , Tetsuro Takumi 1 , Satoko Masai 1 , Ayako Anraku 1 , Goji Tomita 1 1Department of Ophthalmology, Toho University Ohashi Medical Center pp.1576-1584
Published Date 2020/12/15
DOI https://doi.org/10.11477/mf.1410213861
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Abstract Purpose:To investigate the association between the changes of structure and blood flow waveform in optic nerve head(ONH)before and after trabeculectomy(TLE)in open-angle glaucoma.

Methods:A total of 28 eyes of 28 patients achieved a ≥20% reduction in IOP at three months after TLE were included. We measured Bruch's membrane opening minimum rim width(BMO-MRW)and retinal nerve fiber layer thickness(RNFLT)using SD-OCT, the mean blur rate in tissue area(MBRT)as a relative measure of the blood flow and blood flow waveforms in optic nerve head using LSFG before surgery and 3 months postoperatively. Wilcoxon's signed-rank test was used to analyze the differences in these parameters before and after TLE. Linear and multiple regression analyses were used to determine factors related to the rates of change in the BMO-MRW and RNFLT.

Results:Axial length decreased and ocular perfusion pressure increased significantly at 3 months after TLE(p<0.05). BMO-MRW increased significantly(p=0.001), but RNFLT did not change(p=0.294). There was no significant change in MBRT. In blood flow waveforms, fluctuation and flow acceleration index(FAI)decreased(p=0.020 and p=0.002, respectively)after TLE. In multiple regression analyses, the rate of change in resistivity index was a significantly related factor to that of BMO-MRW(β=0.382, p=0.045), and the rate of change in FAI was a significant related factor to that of RNFLT(β=0.396, p=0.037).

Conclusions:There was an association between the changes of structure and blood flow waveform in ONH before and after TLE.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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