A five-year review of optic neuritis in children at Wakayama Medical University Hospital Yudai Yamaguchi 1 , Kumi Shirai 1 , Takayoshi Sumioka 1 , Yukihisa Takada 1 , Hiroki Iwanishi 1 , Yuka Okada 1 , Toshiyuki Takahashi 2 , Kimihiko Kaneko 3 , Shizuya Saika 1 1Department of Ophthalmology, Wakayama Medical School 2Department of Neurology, Tohoku University, Yonezawa Hospital 3Department of Neurology, Tohoku University, Miyagi Hospital pp.341-346
Published Date 2019/3/15
DOI https://doi.org/10.11477/mf.1410213080
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Abstract Purpose:To report cases of pediatric optic neuritis seen by us during 5 years through 2018.

Cases:There were 5 cases, comprising 2 males and 3 females. The age ranged from 6 to 12 years, average 9 years. Three cases were unilaterally and two were bilaterally affected. They were diagnosed after the definition by International Pediatric MS study Group.

Findings and Clinical Course:Two cases were associated with acute disseminated encephalomyelitis. One case each was diagnosed as clinically isolated syndrome, as idiopathic optic neuritis, and as multiple sclerosis. Anti-MOG antibody was positive in 2 cases. Anti-aquaporin 4 antibody was negative in all the cases. Steroid pulse therapy was effective in all the cases, with 2 cases who showed recurrence. Two cases positive for anti-MOG antibody were also treated by high-dose gamma globulin, with immunosorbent therapy in one case. Visual acuity in logMAR averaged 1.6±0.8 initially and 0.06±0.2 after treatment.

Conclusion:Visual acuity improved in all cases of pediatric optic neuritis. There were recurrences involving not only the optic nerve but also the intracranial portion and spinal cord.

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