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Japanese

Pulsed corticosteroid therapy was effective in a case of optic neuritis positive for antibodies against myelin oligodendrocyte glycoprotein(MOG) Takashi Takeuchi 1 , Masashi Kojima 1 , Nahoko Ogata 1 1Department of Ophthalmology, Nara Medical University pp.1259-1263
Published Date 2017/8/15
DOI https://doi.org/10.11477/mf.1410212376
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Abstract Purpose:To report a case of optic neuritis who was positive for antibodies against myelin oligodendrocyte glycoprotein(MOG)and who responded to pulsed corticosteroid by recovering from the initial visual acuity of no light perception.

Case:A 29-year-old man was referred to us for suspected optic neuritis in the left eye since 3 days before. He had had bilateral paranasal sinusitis one month before.

Findings and Clinical Course:Corrected visual acuity was 1.5 in the right eye and 0.9 in the left. The left eye showed swelling of optic disc with relative afferent pupillary defect. Magnetic resonance imaging(MRI)showed swollen left optic nerve. Visual acuity in the left eye decreased to no light perception 5 days later. He started receiving pulsed corticosteroid therapy immediately. Visual acuity started to improve 2 days later and recovered to 1.0 four weeks later. He started receiving pulsed corticosteroid therapy immediately. The blood test was positive for anti-myelin oligodendrocyte glycoprotein antibody, leading to the diagnosis of anti-MOG antibody-positive optic neuritis. He developed acute disseminated encephalomyelitis 3 months later that responded to pulsed corticosteroid therapy.

Conclusion:Pulsed corticosteroid therapy was effective in the present case of optic neuritis positive for antibodies against myelin oligodendrocyte glycoprotein.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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