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Subconjunctival amphotericin B in the treatment of candida albicans endophthalmitis Shinya Kimura 1 , Masao Fujii 1 , Kazuo Mukuno 1 1Dept of Ophthalmol, Sch of Med, Univ of Kitasato pp.1825-1831
Published Date 1989/11/15
DOI https://doi.org/10.11477/mf.1410211047
  • Abstract
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We treated 3 cases of endophthalmitis due to candida albicans with different therapeutic modalities. A 49-year-old male developed systemic candidiasis with bilateral ocular involvement 2 months after multiple injury due to traffic accident. Treatment with intravenous infusion of amphoter-icin B resulted in macular and vitreous scarring. A 53-year-old male developed systemic candidiasis during treatment for septicemia. Both eyes manifested vitreous abscess. After peroral 5-fluor-ocytosine and vitrectomy with intravitreal am-photericin B injection in the right eye, both eyesresulted in macular scarring. A 47-year-old female developed bilateral endophthalmitis during intra-venous prednisolone therapy for nephrosis which developed after hysterectomy. She was treated with subconjunctival injection of amphotericin B because of allergic reaction to the drug when ad-ministered intravenously. Final visual acuity of 0.5 was attained in the treated eye. Administration of amphotericin B through subconjunctival route seemed to be of value either as adjuncto or as alternative to systemic one.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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