硝子体腔よりの螢光色素の流出に関する検討—（第3報）ぶどう膜炎の二相分離解析法

Fluorophotometric evaluation of outward transport of fluorescein out of the vitreous.:III. Biphasic decay analysis in uveitis

　種々のぶどう膜炎14眼に，螢光色素10mg／kgを静注し，5〜48時間後までkinetic vit-reous fluorophotometryを行い，その結果に二相分離解析法を応用した．

　血液房水柵，内・外血液網膜柵がおかされていると考えられるベーチェット病（眼底型）では早期の色素消失定数（KV1）の低下が著しく，眼内よりの色素の能動輸送能の低下が示唆された．原田病にも同様の所見がみられた．

　一方，前部ぶどう膜炎では，二相性について正常眼と有意差はなかった．

We evaluated 14 eyes with uveitis by means of kinetic vitreous fluorophotometery. The series in-cluded anterior uveitis 4 eyes, Harada's disease 4, posterior type Behçet's disease 4 and unclassified posterior uveitis 2. Another series of 15 eyes served as control. Vitreous fluorophotometry was repeated 5 to 48 hours after intravenous injection of10 mg/kg fluorescein sodium. The data were then processed through biphasic decay analysis.

We observed consistent decrease in KVi in Har-ada's and Behçet's diseases in which the blood -retinal and blood-aqueous barriers are disrupted.The finding seemed to suggest the disturbance of active transport facility from the vitreous cavity. In eyes with anterior uveitis, on the other hand, we observed little difference from normal controls.

Rinsho Ganka (Jpn J Clin Ophthalmol) 42(6) : 635-637, 1988