糖尿病性網膜症における血小板機能異常

Platelet function in the circulating blood in diabetic retinopathy

　糖尿病性網膜症患者と健常者の血小板凝集能を測定したところ，以下の結果を得た．

（1）単純型網膜症（SDR）群において，Adenosine　diphosphate （ADP）1μM,3μM付加の最大凝集率が統計学的有意義差をもって上昇していることが確認された（P＜0.01）．

（2）コラーゲン0.5μg／ml付加で正常群は全例2次凝集を示さなかった．

（3）コラーゲン0.5μ9／ml付加でSDR群において1部，増進型網膜症（PDR）群において全例が2次凝集を示した．

　従来の糖尿病における血小板凝集能に関する報告では，中，高濃度ADP付加によるものが広く行われていたが，今回我々が設定した低濃度ADPおよびコラーゲン付加による検査も，今後十分に検討されるべき価値があると思われた．

We determined the patterns of adenosine diphosphate (ADP)-and collagen-induced platelet aggregation in patients with simple diabetic retinopathy (59 cases), proliferative diabetic retinopathy (8) and 36 non-dia-betic subjects as control.

Cases with simple diabetic retinopathy (SDR) showed higher rates of maximum plate aggregation in response to low ADP concentrations (1 and 3μM) than controls (p<0.01). Several cases with SDR and all the cases with proliferative diabetic retinopathy manifested secondary aggregation induced by 0.5μM of collagen.The secondary aggregation was consistently absent in the controls.

These findings suggest that platelet aggregation in-duced by ADP and collagen of low concentration pro-mises to be of prognostic value in diabetic retinopathy. The secondary aggregation was consistently absent in the controls.

These findings suggest that platelet aggregation in-duced by ADP and collagen of low concentration pro-mises to be of prognostic value in diabetic retinopathy.

Rinsho Ganka (Jpn J Clin Ophthalmol) 40(5) : 481-484, 1986