Vogt—小柳—原田病患者のEpstein-Barrウイルス抗体価

Epstein-Barr virus-specific antibodies in patients with Vogt-Koyanagi-Harada disease

　京大病院眼科ぶどう膜炎外来に通院中の，Vogt-小柳-原田病患者23名（Vogt-小柳病11名，原田病12名）および対照健康人144名についてEpstein-Barr （EB）ウイルス抗体価の変動を検討した．Suppressor T cellの機能を反映する抗Viro-Capsid-Antigcn （VCA）抗体価の幾何平均は，Vogt-小柳病患者群で対照群と比べて高値を示し，Killer T cellの機能を反映する抗Epstein-Barr Virus Nuclear Antigen （EBNA）抗体価の幾何平均は，原田病患者群で対照群と比べて低値を示した．同じ疾患群であっても，前部ぶどう膜炎では抗VCA抗体価が高値を示し，後部ぶどう膜炎では抗EBNA抗体価が低値を示した事は，前に報告した一般のぶどう膜炎と同じ傾向を示した．これらの事より炎症反応の場の相異により，EBウイルスに対する免疫応答も異なってくるのではないかと考えた．

We evaluated the antibody titers specific for Epstein-Barr virus in 23 patients with Vogt-Ko-yanagi-Harada disease, including 11 with Vogt-Ko-yanagi disease and 12 with Harada disease. Patients with Vogt-Koyanagi disease showed high values in the geometric mean titers of anti-viro-capsid-anti-gen than control and patients with Harada disease. Patients with Harada disease showed lower values in the geometric mean titers of anti-Epstein-Barr-virus nuclear antigen than control and patients with Vogt-Koyanagi disease.

These data suggest that there may be an immu-nological difference between Vogt-Koyanagi disease and Harada disease, although Vogt-Koyanagi dise-ase and Harada disease are included in the same clinical entity.

The difference between the pattern of antibodies in patients with Vogt-Koyanagi dise-ase and those with Harada disease were found to resemble the difference between the antibody pat-terns in anterior uveitis and pan-uveitis reported previously.