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Japanese

Studies on the ophthalmic use of Erythromycin and its dervatives Ⅲ Studies on ocular penetration Kazuo Ishida 1 1Department of Ophthalmology, Niigata University School of Medecine pp.731-734
Published Date 1963/5/15
DOI https://doi.org/10.11477/mf.1410202738
  • Abstract
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The results of the penetration of Erythro-mycin (EM), Erythromycin propionate (EP) and Propionyl Erythromycin Lauryl Salfate (PELS) into normal rabbits eyes by the oral administration were summerized as follows.

1) The serum and aqueous levels after the oral administration of EM 100mg were <0.02 mcg/cc in 8 of 9 rabbits, and the levels post administration of EP 100mg or PELS 100mg were <0.02mcg/cc in a half of 9 rabbits res-pectively.

2) A peak serum and aquseous concent-ration receiving 500mg of EM, EP and PELS was reached after two to three hours, and PELS produced highest concentration, and EP higher than EM.


Copyright © 1963, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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