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Japanese

A case of bilateral retrobulbar neuritis as manifestation of anti-neutrophil cytoplasm circulating antibody(ANCA)following systemic propylthiouracil Takashi Kudo 1 , Kaori Suzuki 1 , Yukihiko Suzuki 1 , Asaka Kudo 1 , Satomi Kimura 1 , Tadashi Ito 1 , Kimiyo Katayama 1 , Mitsuru Nakazawa 1 1Dept of Opthalmol, Hirosaki Univ Grad Sch of Med pp.209-213
Published Date 2013/2/15
DOI https://doi.org/10.11477/mf.1410104605
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Abstract. Purpose:To report a case of bilateral retrobulbar neuritis as manifestation of anti-neutrophil cytoplasm circulating antibody(ANCA)-associated vasculitis following systemic propylthiouracil. Case:A 47-year-old woman presented with bilaterally impaired vision with headache since one week before. She had been treated with peroral propylthiouracil for Graves disease since 38 months before. The treatment was discontinued 24 months before for skin eruption due to ANCA-related vasculitis. The treatment was started again 2 months before and was discontinued 6 weeks later for headache and fever. Findings:Corrected visual acuity was 0.01 right and 0.03 left. Both eyes showed central scotoma. Magnetic resonance imaging(MRI)showed enhanced optic nerve sheath, leading to the diagnosis of bilateral retrobulbar neuritis. Pulsed corticosteroid therapy was followed by visual acuity of 1.2 in either eye 3 days later. Conclusion:This case illustrates that retrobulbar neuritis may be induced by ANCA-associated vasculitis following systemic propylthiouracil.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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