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Serum levels of insulin-like growth factor-1 and vascular endothelial growth factor in an infant with retinopathy of prematurity needing vitreous surgery Yuta Saito 1 , Isamu Ito 1 , Takako Nakanishi-Ueda 2 , Masahiko Murase 3 , Tomomi Segami 3 , Atsuo Miyazawa 3 , Hiroshi Sasaki 3 , Katsumi Mizuno 3 , Toshihiko Ueda 1 , Kazuo Itabashi 3 , Hajime Yasuhara 2 , Ryohei Koide 1 1Dept of Ophthalmol,Showa Univ Sch of Med 2Dept of Pharmacol,Showa Univ Sch of Med 3Dept of Pediatrics,Showa Univ Sch of Med pp.1279-1283
Published Date 2011/8/15
DOI https://doi.org/10.11477/mf.1410103791
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Abstract. Purpose:To report serum levels of insulin-like growth factor-1(IGF-1)and vascular endothelial growth factor(VEGF)in an infant with severe retinopathy of prematurity(ROP). Case:A female infant was born at the gestational age of 27 weeks weighing 409 g. Ophthalmological control was started on day 24 after birth. The ROP developed to zone Ⅱ stage 3 on day 87 needing photocoagulation. Both eyes received intravitreal bevacizumab on day 108. Right eye received encircling,left eye received vitrectomy,both eyes received photocoagulation on day 214 with eventually favorable outcome. Findings:Serum level of IGF-1 was below 20 ng/ml from birth until day 108. Level of VEGF was between 215 and 440 pg/ml until day 77 and increased to 1,320 pg/ml on day 84. Conclusion:Serum level of IGF-1 and VEGF in this prematurely born infant remained very low until the adjusted gestational age of 40 weeks. Level of VEGF started to increase thereafter.


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電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院

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