Rinsho Ganka Volume 65, Issue 6 (June 2011)

Topical and systemic ganciclovir was effective in a case of cytomegalovirus corneal endotheliitis Takenori Inomata 1,2 , Atsushi Takeda 2 , Rio Honda 2 , Asaki Matsui 2 , Hiroshi Toshida 2 , Toshihiko Ohta 2 , Michiaki Koike 3 , Kiyomi Yata 4 , Akira Murakami 1 1Dept of Ophthalmol,Juntendo Univ Sch of Med 2Dept of Ophthalmol,Juntendo Shizuoka Hosp 3Dept of Hematol,Juntendo Shizuoka Hosp 4Yata Eye Clin pp.875-879
Published Date 2011/6/15
DOI https://doi.org/10.11477/mf.1410103695
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Abstract. Purpose:To report a case of cytomegalovirus corneal endotheliitis that responded to topical and systemic ganciclovir. Case:A 45-year-old male presented with corneal edema in the left eye since 3 months before. The left eye had attacks of elevated intraocular pressure(IOP)and had been diagnosed with Posner-Schlossman syndrome. Findings:Corrected visual acuity was 1.2 right and 0.9 left. IOP was 13 mmHg right and 30 mmHg left. The left cornea showed edema in the upper quadrant with keratic precipitates. The aqueous humor showed cytomegalovirus DNA when processed by PCR. The left eye was treated by topical and intravenous ganciclovir. The cornea became transparent and IOP normalized 2 weeks later. Conclusion:This case illustrates that tapping of aqueous and processing by PCR may be effective in the diagnosis of cytomegalovirus corneal endotheliitis and that it may respond to topical and systemic ganciclovir.

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65巻6号 (2011年6月)
電子版ISSN 1882-1308 印刷版ISSN 0370-5579 医学書院