腰下肢痛に対するプロスタグランディンI2製剤のQuality of Life改善効果

Effect of Prostaglandin I2 on the Quality of Life Associated with Back Pain and Leg Pain

　経口プロスタサイクリン誘導体製剤は，慢性動脈閉塞症の症状を改善する．本研究では腰部脊柱管狭窄症66例に本剤を投与し，腰下肢痛・関連するQOL・跛行出現距離につき，12週間の推移を評価した．疼痛とQOLレベルをVisual Analogue Scale，日本整形外科学会腰痛疾患治療成績判定基準，日本語版ロランド・モリス問診票で，跛行出現距離を問診で評価した．疼痛・QOLレベル・跛行出現距離のいずれもが投与12週後までに有意に改善した．本剤は腰部脊柱管狭窄症に対する効果的な保存的療法の一つである．

　Oral beraprost sodium improves the manifestations of arteriosclerosis obliterans, and in this study it was used to treat 66 patients with lumbar spinal canal stenosis.　Back pain, leg pain, and associated QOL were evaluated by means of a Visual Analogue Scale, the JOA score, and the Japanese version of the Roland-Morris Disability Questionnaire, and the distance walked before the onset of intermittent claudication was evaluated by questioning each patient periodically.　The pain, QOL level, and the distance walked before the onset of intermittent claudication had all improved significantly by 12 weeks after the start of treatment.　Beraprost sodium is an effective choice of conservative treatment for lumbar spinal canal stenosis.