腰下肢痛に対するシロスタゾール製剤のQuality of Life改善効果

Effect of Cilostazol on the Quality of Life Associated With Back Pain and Leg Pain

　抗血小板剤シロスタゾール製剤は，閉塞性動脈硬化症の症状を改善する．本研究では腰部脊柱管狭窄症例20例に本剤を投与し，腰下肢痛・関連するquality of life(QOL)・跛行出現距離の4週間の推移を評価した．疼痛とQOLレベルをVisual Analogue Scale，日本整形外科学会腰痛疾患治療成績判定基準，日本語版ロランド・モリス問診票で，跛行出現距離を問診で評価した．疼痛・QOLレベルとも投与4週後に有意に改善し，跛行出現距離には改善の兆候がみられた．本剤は腰部脊柱管狭窄症に対する効果的な保存的療法の一つである．

　Anti-platelet aggregatory cilostazol improves the signs of arteriosclerosis obliterans.　In this study, 20 participants with lumbar spinal canal stenosis were administered this drug.　Back pain, leg pain and associate QOL were estimated Visual Analogue Scale, Assessment of Treatment for Low Back Pain, Japanese Orthopaedic Association (JOA) score, and the Japanese version of the Roland-Morris Disability Questionnaire, and the walking distance at which intermittent claudication evaluated by questioning each patient periodically.　Both pain and the QOL level improved significantly after 4 weeks of treatment with cilostamide.　Intermittent claudication occured at an increased walking distance, showing improvement in the patient's condition.　There fore this drug is an effective choice of conservative treatment for lumbar spinal canal stenosis.