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Positive Chronotropic Effect of Cilostazol in Patients with Chronic Bradycardic Atrial Fibrillation Nobusuke Kondou 1 , Koukou Ri 1 , Takeshi Shikama 1 , Tomonobu Terada 2 , Yukiko Irie 2 , Michihiko Saitou 2 , Youko Ishiwatari 2 , Shigeo Kataoka 2 1Chousei Municipal Hospital, Division of Internal Medicine 2Chousei Municipal Hospital, Division of Physiological Laboratory Keyword: シロスタゾール , 徐脈性心房細動 , 変時作用 , cilostazol , bradycardic atrial fibrillation , chronotropic effect pp.705-710
Published Date 2001/7/15
DOI https://doi.org/10.11477/mf.1404902322
  • Abstract
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 The purpose of this study is the evaluation of positivechronotropic effect of cilostazol in patients with chronicasymptomatic bradycardic atrial fibrillation. Weexamined in twenty patients comprising 14 patientswithout heart rate control treatment (group A) and 6patients with low-dose carteolol therapy (group B). 24hour ambulatory Holter ECG was performed before andafter administration of cilostazol. Cilostazol dosage was50mg twice daily. During this study we find no severeadverse effect of cilostazol except for mild headache in1 patient.

 After administration of cilostazol to group A, maximum R-R interval shortened (p<0.05), amount of pauseevent decreased (p<0.001), minimum HR increased(p <0.01) increased. Maximum HR and mean HR didnot show remarkable change. In group B, these allparameters by 24-hour Holter ECG did not showremarkable change, but 2 patients of group B showedmild improvement of these parameters. In detailedinvestigation of cilostazol effect, shortening of maximum R-R interval and decrease of pause event weremore prominent in patients with longer maximum Rintervals and more pause event. In group B, all BolterECG parameters did not improved, but we could findweak chronotropic effect of cilostazol in 2 patients ofgroup B. This result revealed the hypothesis that themechanism of chronotropic effect of cilostazol was notonly beta-adrenergic stimulation but also other unknown mechanism. In conclusion, cilostazol had abeneficial positive chronotropic effect in patients withbradycardic atrial fibrillation.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1200 印刷版ISSN 0452-3458 医学書院

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