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Efficacy and Limitations of Intravenous Lipoprostaglandin E1 Infusion against Neurogenic Intermittent Claudication in Patients with Lumbar Spinal Canal Stenosis Yuzuru Okamoto 1 , Yasuhiro Oikawa 1 , Hideshige Moriya 1 1Department of Orthopaedic Surgery, Kashima Rosai Hospital Keyword: リポプロスタグランディンE1 , lipoprostaglandin E1 , lipo-PGE1 , 腰部脊柱管狭窄症 , lumbar spinal canal stenosis , 神経性間欠跛行 , neurogenic intermittent claudication pp.433-436
Published Date 2010/5/25
DOI https://doi.org/10.11477/mf.1408101729
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 We investigated the efficacy of intravenous infusion of lipoprostaglandin E1 (lipo-PGE1) against neurogenic intermittent claudication (NIC) in patients with lumbar spinal canal stenosis (LCS). Lipo-PGE1 (5μg daily for 14 consecutive days) was administered by intravenous infusion to 37 patients who had not responded well to oral PGE1 therapy. The patients' average maximum walking distance had significantly improved after treatment. The patients with the radicular type of NIC had significantly better results than the patients with the cauda equina type or mixed type. After an average follow-up period of 17 months therapeutic efficacy has continued in 12 patients, but the 20 other patients required surgery after treatment. Intravenous lipo-PGE1 therapy appeared to provide limited efficacy against NIC in LCS patients.


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電子版ISSN 1882-1286 印刷版ISSN 0557-0433 医学書院

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