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Japanese

IMMUNOHISTOCHENICAL STUDY ON DISTRIBUTION OF TRANSTHYRETIN IN NORMAL HUMAN BRAIN TISSUE AND TUMORS Katsuzo Kunishio 1 , Tetsuya Shiraishi 1 , Nobuya Mishima 1 , Nobuhiko Matsumi 1 , Takashi Tamiya 1 , Chiho Honda 1 , Kengo Matsumoto 1 , Tomohisa Furuta 1 , Akira Nishimoto 1 1Department of Neurological Surgery, Okayama University Medical School pp.245-249
Published Date 1989/3/1
DOI https://doi.org/10.11477/mf.1406206272
  • Abstract
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Immunohistochemical examination of trans-thyretin (TTR), which is known to be synthesized in the epithelial cells of the choroid plexus as well as in the liver cells, was carried out on normalbrain tissues and 84 human brain tumors, using a peroxidase-antiperoxidase (PAP) technique. TTR was demonstrated diffusely and strongly in the cytoplasm of normal choroid plexus cells, but not in ependyma and other tissues of normal brain. In all of 10 choroid plexus papillomas, TTR was found within the cytoplasm of tumor cells. In contrast, neither the two papillary ependymonas nor any other brain tumors contained TTR. Among the choroid plexus papillomas, some cases showed clear positive reactions in almost all tumor cells, while others had only a few TTR-positive cells. With these immunohistochemical findings, TTR proved a very useful marker of normal choroid plexus and choroid plexus papilloma.


Copyright © 1989, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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