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BILATERAL CAROTID ARTERY LIGATION IN RAT SERIAL PATHOLOGY OF THE OPTIC NERVE Junichi Takamatsu 1,2 1Department of Neuropsychiatry, Kumamoto University School of Medicine 2Present Address: Hizenn National Mental Hospital pp.739-746
Published Date 1988/8/1
DOI https://doi.org/10.11477/mf.1406206153
  • Abstract
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Ischemic desease is common in the central ner-vous system, and has been extensively studied both clinically and neuropahtologically. Experi-mental models have been designed for the repro-duction of cerebral infarct. Advanced optic nerve atrophy was recently described in Long-Evans pigmented rat 16 weeks following bilateral carotid artery ligation. Marked change in the retina and its vessels had previously been observed by the fundoscopy and the fluorescein angiography. Serial alteration of the optic nerve was studied on the same experimental model for one month ; each two rats for two days, one week, two weeks, one month after the operation, in which the common carotid arteries were ligated just before the bifur-cation. A mid-portion of the optic nerve attached to the brain was dissected out and cross-sections were prepared to examine under the light and the electron microscope. Unequivocal pathology was demonstrated in six among eight rats operated. There was no significant change both in remain-ing two rats and two sham-operated controls. Two-days-postoperative rats developed obvious optic nerve swelling with vacuolar appearance.They consisted of numerous distended axons, con-taining empty space or flocculus materials. Both intra- and extracellular edema were seen at this time, when vascular beds were transiently dis-rupted. Necrotic cells and other residual materials were also present in the wide interstitial space. In the following one or two weeks, the edema disappeared and many distended axons contained a lot of organelles, such as mitochondria and/or neurofilaments. In the same period severely dama-ged axons collapsed, occasionally concomitant with homogenous dense axoplasm. There were as many protoplasmic astrocytes as phagocytic cells contain-ing remnants of the tissue or lipid droplets. Vascular beds appeared to be reconstructed. And then, the majority of the optic nerves were pro-gressively replaced with compactly packed glial processes during the latter half of the experiment, whereas still being present a variety of the alte-ration, even normal axons. Myelin sheath was preserved relatively longer, resulting in the pre-sence of axons with the empty center. The patho-logy of this experiment could be mainly due to Wallerian degeneration secondary to the damage of the ganglion cell in the retina. However di-rect ischemic effect to the optic nerve itself might accelerated the interstitial changes such as floody edema and astroglial reaction. The early optic nerve swelling was compared with the papillede-ma. Author felt this model would be as much as useful for studying ischemic disease in the central nervous system as other known ischemic models.


Copyright © 1988, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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