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Japanese

THE INFLUENCES OF NEUROTRANSMITTERS ON THE TRAUMATIC UNCONSCIOUSNESS, IMMEDIATE CONVULSION AND MORTALITY IN THE EXPERIMENTAL MICE MODEL Mamoru Sasaki 1 , Keizo Hashizume 1 , Shinya Manaka 2,3 , Kintomo Takakura 2 1Department of Neurosurgery, Self-Defense Forces Central Hospital 2Department of Neurosurgery, Faculty of Medicine, University of Tokyo 3Teikyou University School of Medicine Ichihara Hospital pp.983-990
Published Date 1987/10/1
DOI https://doi.org/10.11477/mf.1406205995
  • Abstract
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In order to clearing the influence of neurotrans-mitters in concussive unconsciousness, immediate convulsion and mortality, the following experi-ments were performed.

Awake male mice of dd-strain were restrained and subjected to head injury using a bakelite weight of 30 gm dropped from a height of 20 cm on to the skull. This injury resulted in immediate loss of consciousness in 100%, convulsive seizure in 66% and death in 30% of animals. The severity of consciousness disturbance was evaluated by two parameters ; ( 1 ) time interval required for the recovery of righting reflex (RR) and ( 2 ) time interval for the recovery of spontaneous movement (SM). Agonist or antagonist of various neurotrans-mitters was given intraperitoneally O.5 or 2 hours before injury.

The following results were obtained although some of them were statistically not significant.Physostigmine shortened both RR (p<0. 1) and SM (p<0. 01), whereas scopolamine did not change these intervals. Atropine sulfate shortened both of them. Nevertheless, atropine methylbromide, which dose not pass through blood-brain-barrier, also had same effects. Methamphetamine shortened both RR (p<0. 1) and SM (p<0. 05), whereas haloperidol prolonged these intervals. 5-HTP shortened RR (p<0. 05), but prolonged SM (p< O. 1). Methysergide shortened both RR (p<0. 05) and SM (p <O. 01). Convulsive seizure was supress-ed by physostigmine (p<0. 01) or 5-HTP (p< 0.20).

These results suggested that supression of do-paminergic and cholinergic systems, and/or activa-tion of serotonergic system contribute to concussive unconsciousness.


Copyright © 1987, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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