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Brain and Nerve No to Shinkei Volume 37, Issue 11 （November 1985）

Brain and Nerve 脳と神経 37巻11号（1985年11月発行）

Japanese English

原著

悪性脳腫瘍患者に対するIgG-Fc receptor陽性T細胞測定の臨床免疫学的意義 CLINICOIMMUNOLOGICAL VALUES OF MEASUREMENT OF IGG-FC RECEPTOR POSITIVE T CELLS IN THE PATIENTS WITH MALIGNANT BRAIN TUMORS 吉田誠一 ¹ , 原直行 ¹ , 高井信行 ¹ , 斉藤隆史 ¹ , 田中隆一 ¹ Seiichi Yoshida ¹ , Naoyuki Hara ¹ , Nobuyuki Takai ¹ , Takafumi Saito ¹ , Ryuichi Tanaka ¹ ¹新潟大学脳研究所脳神経外科 ¹Department of Neurosurgery, Brain Research Institute, Niigata University pp.1073-1078

発行日 1985年11月1日 Published Date 1985/11/1

DOI https://doi.org/10.11477/mf.1406205610

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Abstract 文献概要
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　抄録　Glioma患者105例を中心に，末梢血中のTγ紬胞の検討を行い，次の結果を得た。1） Tγ細胞の平均値は，健常人で6.54±1.6％，悪性glioma患者で15.4±4.8％，転移性脳腫瘍患揖で14.9±3.2％，他の良性脳腫瘍群で8.1±3.7％となり，悪性群で有意な増加をみた。2）悪性glioma患者のTγ細胞の変動を検討すると，予後良好群ではTγ細胞は減少し続けたが，予後不良群では，病状悪化に伴うTγ細胞の増加傾向を認めた。3）悪性g1ioma患者のTγ細胞と　ADCC　活性とは有意に（P＜0.01）正の相関を示し，更に，この増加している患者Tγ細胞は，健常人のTγ細胞に比べ，より強いADCC活性を示した。4） P．H．A．およびCon．Aに対するリンパ球幼若化能とTγ細胞は，悪性glioma患者において負の相関を示し（P．H．A．；p＜0.001,r＝−0.742,Con．A；p＜0．OO1,r＝—O．662），Tγ細胞の強いADCC活性が考えられた。5） Tγ細胞とIAP値との間には相関関係は認められなかった。

It has recently been shown that human T-cell subpopulation can be identified functionally via surface receptors for Fc fragment of immunoglo-bulins. We detected peripheral blccd T-cells bear-ing the Fc receptor for IgG molecules (Tγ cell) in patients with brain tumors who manifested a variety of immunological abnormalities. We also analyzed immunological values of Tγ cells which were thought to be suppressor and/or a part of killer T cells, comparing with other immunological parameters.

The percentage of Tγ cells was significantly higher in patients with malignant brain tumors than in normal controls (6.54±1.6%). The values of Tγ cells in patients with glioma, metastatic brain tumor, benign brain tumor were 15.4±4.8%, 14.9±3.2%, and 8.1 ±3.7%, respectively. In the patients with glioma, the values increased in the uncontrolled group compared with the well-controlled group. Furthermore, the values were decreased by surgical removal of the tumor.

On immunological study of Tγ cells in the pa-tients with glioma, there was a definite correlation between the values of Tγ cells and ADCC acti-vity. Furthermore, the Tγ cells in the patients showed higher ADCC activity than in normal controls. The values of Tγ cells also correlated with blastogenesis of the peripheral blood lym-phocytes by PHA (r=- O.742, p<O.001) and Con A (r=-0.662, p<0.001).

These results suggest that Tγ cells are playing two important roles in patients with glioma such as suppressor function and ADCC activity, and that these cells may change according to the tu-mor growth. Therefore, measurements of Tγ cells are useful to grasp the immunological condition of these patients.