脳血管障害患者の急性期における凝固・線溶能の特徴

CORRELATION BETWEEN COAGULATION AND FIBRINOLYSIS IN PATIENT WITH CEREBROVASCULAR ACCIDENT AT ACUTE STAGE

　抄録　急性期脳血管障害95例の凝固・線溶能について検討を加え，次の結果をえた。

1）脳梗塞ではAT-IIIが有意に低値となることから，梗塞発現時の凝固能亢進状態が観察された。

Ninety five patients with cerebrovascular acci-dents were studied on their coagulation and fibrinolysis at acute stage of their onset. From the data collected in the present study, following findings were obtained ;

1) Hypercoagulable state, which are responsible for the decreased antithrombin III levels, was observed at acute stage of cerebral infarction.

2) Findings from patients with cerebral hemor-rhage were normal antithrombin III levels and slightly decreased az-plasmin inhibitor. These imply the fact of increased fibrinolytic activities. It is suggested that increased fibrinolysis are secondary reaction of cerebral hemorrhage.

3) Findings from patients with subarachnoid hemorrhage showed hypercoagulable state and increased fibrinolytic activities. It is considered that subarachnoid hemorrhage might have mostly a preparatory condition of disseminated intra-vascular coagulation among cerebrovascular acci-dents.