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AN AUTOPSY CASE OF PARKINSON'S DISEASE ASSOCIATED CLINICALLY WITH DEMENTIA TERMINATING IN AKINETIC MUTISM AND PATHOLOGICALLY WITH MULTIPLE LEWY'S BODIES IN THE CEREBRAL CORTEX Riki Okeda 1 , Teruo Kayano 2 , Nobuaki Funata 1 , Takuya Kojima 3 , Masako Miki 3 , Hisayuki Iwama 3 1Department of Pathology, Medical Research Institute of Tokyo Medical and Dental University 2Department of Oral Pathology, Dental Faculty of Tokyo Medical and Dental University 3Department of Psychiatry, Medical Faculty of Tokyo Medical and Dental University pp.761-767
Published Date 1982/8/1
DOI https://doi.org/10.11477/mf.1406204981
  • Abstract
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An autopsy case of a 50 year-old male with Par-kinson's disease associated with multiple Lewy bodies in the cerebral cortex was reported. His clinical symptoms began at the age of 26 with the speech and actions indicative of a persecution complex accompanied by irritability and were followed by progressive dementia from the age of 37 and Perkinsonism since the age of 41. He was in a state of akinetic mutism thereafter till his death at the age of 50.

Autopsy disclosed in addition to the typical findings of Parkinson's disease in the brain stem multiple intracytoplasmic Lewy bodies in medium-sized neurons of the fifth and sixth layers of the cerebral cortex. They were atypical in the sense that they did not have any haloes. They were especially numerous in the cingulate gyrus. In addition, findings of non-specific neuronal dege-neration were obtained in the cerebral cortex such as cellular atrophy with massive deposition of lipofuscin pigments, central chromatolysis, cell loss and cellular gliosis in the third, fifth and sixth layers. These neuronal findings were also pro-minent in the cingulate gyrus. Such senile changes as senile plaques or granulo-vacuolar degeneration were not found, although there were a few foci of neurofibrillary degeneration in the hippocampal gyrus. Histochemically and electron microscopically, no difference was observed in the constituents of Lewy bodies between the brain stem and the cerebral cortex.

Such autopsy findings and a review of the literature indicate that the dementia in this case may be related not only to the presence of Lewy bodies but also to the above-described, non-specific neuronal degeneration in the bilateral cingulate gyri and surrounding frontal gyri. The standpoint of regarding a Parkinson's disease with multiple Lewy bodies in the cerebral cortex as an inde-pendent disease entity was criticized.


Copyright © 1982, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 2185-405X 印刷版ISSN 0006-8969 医学書院

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